Based on limited published evidence, ANTKMT is a mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases (ANT2/SLC25A5 and ANT3/SLC25A6) at lysine-52, with probable activity toward ANT1/SLC25A4 1. This trimethylation regulates mitochondrial respiration and ATP synthesis. ANTKMT-deficient cells exhibit increased mitochondrial respiration compared to proficient cells, indicating functional significance of ANT methylation 1. The enzyme localizes to mitochondria via a noncanonical targeting sequence. ANTKMT has been identified as a candidate hub gene in hair follicle development pathways 2.