AP1G2 (adaptor protein complex 1 subunit gamma 2) is a core component of the AP-1 vesicular trafficking complex, which regulates intracellular protein sorting and transport at the trans-Golgi network and endosomes 1. As the γ2 subunit of AP-1, AP1G2 forms one of two distinct heterotetrameric AP-1 variants in eukaryotic cells, with specialized functions distinct from AP1G1 (γ1-containing complexes) 1. AP1G2 is particularly critical for lysosomal targeting of internalized proteins; depletion of AP1G2 impairs CD4 and EGFR trafficking to lysosomes, causing accumulation in early endosomes 2. The gene is involved in vesicle-mediated transport pathways including those regulating autophagy and mitophagy 3. Mutations in AP1G2 have been identified as candidate variants associated with multiple disorders: intellectual disability in Middle Eastern families 4, Parkinson's disease risk modification in LRRK2-carrier backgrounds 3, pancreatic cancer susceptibility 5, sudden cardiac arrest in coronary artery disease patients 6, and azoospermia etiology in nonobstructive cases 7. These findings suggest AP1G2 mutations may disrupt fundamental vesicular trafficking mechanisms with broad pathophysiological consequences across neurological, metabolic, and reproductive systems.