AQP11 is a membrane channel protein belonging to the aquaporin superfamily with unique structural features including a modified NPA motif 1. It functions as a water, glycerol, and hydrogen peroxide transporter distributed across multiple tissues including liver, kidney, and brain 23. In the kidney, AQP11 localizes to the endoplasmic reticulum of proximal tubule cells 4. A critical role of AQP11 involves hydrogen peroxide transport across the endoplasmic reticulum membrane, regulating oxidative stress and supporting ER homeostasis 5. In brain astrocytes and neurons, AQP11 expression increases under inflammatory stress (lipopolysaccharide treatment), and functions as a peroxiporin to reduce hydrogen peroxide-induced lipid peroxidation by approximately 50% 5. AQP11 knockdown increases oxidative damage, suggesting protective roles in neuroinflammation and aging-related neurodegeneration 5. Clinically, AQP11 dysregulation associates with renal diseases and colorectal cancer; downregulated AQP11 in colorectal cancer correlates with increased cell adhesion and hepatic metastasis through regulation by miR-152-3p 6. These findings position AQP11 as a biomarker and therapeutic target for kidney pathologies and cancer progression 7.