AQP12B encodes a putative aquaporin water channel protein predicted to form homotetrameric transmembrane channels that facilitate water transport across the plasma membrane along osmotic gradients, contributing to intracellular water homeostasis. The protein's tissue-specific expression and functional role in pancreatic physiology have been investigated, though specific mechanistic details remain limited. Geneticsanalysis revealed that AQP12B harbors a common nonsense variant (p.S152Tfs∗24) with an allele frequency of 15.7% in control populations, including 2.8% homozygous carriers, suggesting the gene is physiologically dispensable for normal pancreatic function 1. Additionally, AQP12B mRNA was not detected in sinonasal tissue samples from either normal controls or chr2 rhinosinusitis patients, indicating limited or absent expression in this tissue type 2. Regarding disease relevance, genetic alterations in AQP12B do not appear to predispose to non-alcoholic chr2 pancreatitis 1. In cataract genetics, AQP12B was sequenced as a candidate gene in a linkage region (2q37-qter) associated with autosomal dominant posterior polar cataracts, but no causative mutations were identified 3. Clinically, AQP12B's apparent functional redundancy in pancreatic tissue and lack of association with common pancreatic disorders suggest limited immediate therapeutic relevance, though its role in other tissues warrants further investigation.