SLC14A1 encodes a urea transporter (UT-B) that primarily mediates passive urea transport across cell membranes, with particular importance in erythrocytes and renal tissues 1. Beyond its classical transport function, SLC14A1 has emerged as a significant player in cancer biology and cellular differentiation. In bladder cancer, SLC14A1 is overexpressed in cancer-associated fibroblasts (CAFs) induced by interferon signaling, where it confers stemness to cancer cells via the WNT5A pathway and correlates with poor patient outcomes and chemotherapy resistance 2. The protein also drives colorectal cancer metastasis through a positive feedback loop with TGF-β signaling, where SLC14A1 stabilizes TβRII protein and enhances epithelial-mesenchymal transition 3. In bone metabolism, SLC14A1 functions as a regulator of mesenchymal stem cell differentiation, with its downregulation promoting adipogenesis while its upregulation favors osteogenesis 4. The transporter is also implicated in acute myeloid leukemia prognosis 5 and endometrial cancer 6. In hemodialysis patients, SLC14A1 expression is significantly elevated and correlates with various clinical parameters, suggesting its involvement in osmotic balance regulation 7. These findings reveal SLC14A1 as a multifunctional protein extending beyond simple urea transport to roles in cancer progression, stem cell differentiation, and metabolic regulation.