AQP7 is an aquaglyceroporin that functions as a homotetrameric transmembrane channel mediating glycerol and water transport across cell membranes along osmotic gradients 1. In adipose tissue, AQP7 mediates glycerol efflux from triglyceride hydrolysis, preventing intracellular accumulation and enabling distribution to other tissues for energy metabolism 1. In the kidney, AQP7 mediates glycerol reabsorption, preventing urinary loss and contributing to energy homeostasis 2. AQP7 is also expressed in pancreatic beta cells and intestinal capillaries, where it regulates intracellular glycerol levels 3. Recently, AQP7 was identified as part of a functional protein complex with CFTR in human sperm, where CFTR inhibition reduces both sperm motility and AQP7-mediated glycerol permeability, suggesting a role in male fertility 4. In cancer biology, AQP7 is involved in tumor growth, migration, and angiogenesis through its aquaglyceroporin function 5. During sepsis, AQP7 contributes to immune cell energy production by facilitating lipid metabolism and promoting glycolysis through p38 signaling 6. Pharmacological modulation of AQP7 expression and function in adipose tissue represents a novel therapeutic approach for obesity and metabolic disorders 1.