AQP3 is an aquaglyceroporin that functions as a transmembrane channel mediating water, glycerol, and H2O2 transport across the plasma membrane 12. Beyond fluid transport, AQP3 plays critical roles in skin hydration and wound healing, with upregulation supporting barrier repair and re-epithelialization 3. AQP3 is also expressed in lens and colonic epithelial cells, where it maintains tissue transparency and participates in water homeostasis 45. In immune responses, AQP3 is essential for leukocyte migration by facilitating osmotic water movement that enables cell shape changes required for tissue infiltration 6. AQP3 promotes inflammatory skin conditions: in rosacea, it activates NF-κB signaling in keratinocytes and STAT3 signaling in CD4+ T cells, driving Th17 differentiation and chemokine production 7. AQP3 significantly contributes to cancer progression through multiple mechanisms. Overexpression correlates with poor prognosis in breast and gastric cancers, where it stimulates cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition 8. In lung adenocarcinoma, AQP3 promotes M2 macrophage polarization via the PPAR-γ/NF-κB axis, modulating IL-6 production and tumor glucose metabolism 9. In hepatocellular carcinoma, AQP3 accumulation induces autophagic cell death through PDPK1-AKT-MTOR pathway inactivation 10. These findings identify AQP3 as a potential therapeutic target for cancer and inflammatory diseases.