ARID5A is a bifunctional nucleic acid-binding protein with distinct roles in transcriptional and post-transcriptional gene regulation. As a DNA-binding protein, ARID5A regulates transcription by binding AT-rich sequences in promoter regions 1 and represses estrogen receptor-mediated transcriptional activation 2. The protein's intrinsically disordered regions flanking its ARID domain modulate DNA-binding specificity and affinity 3. ARID5A functions prominently as an RNA-binding protein that stabilizes inflammatory mRNAs by binding stem-loop structures in 3'UTRs, including IL6, STAT3, TBX21, and TNFRSF4/OX40 4. Upon inflammation, ARID5A translocates to the cytoplasm and stabilizes IL-17-dependent targets including CEBPB and CEBPD, regulating translation through ribosomal interactions 5. ARID5A also stabilizes MAVS mRNA, driving NF-κB and TBK1 activation in cardiac aging 6. Disease relevance is substantial: dysregulation contributes to sepsis, experimental autoimmune encephalomyelitis, glomerulonephritis, and cardiac aging 4756. Additionally, ARID5A functions as a metabolic regulator, acting as a transcriptional repressor of lipid uptake genes in skeletal muscle 8. Targeting ARID5A shows therapeutic promise for inflammatory and autoimmune diseases.