ARMC6 (armadillo repeat containing 6) is a conserved armadillo repeat protein with emerging roles in telomeric and transcriptional regulation. Structurally, ARMC6 contains armadillo repeats that mediate protein-protein interactions 1. The protein binds G-quadruplex motifs in DNA promoter sequences of cancer-related genes (EGFR, VEGF, c-MYC) and in telomeric RNA (TERRA), with preferential recognition of RNA over DNA structures 2. Mechanistically, ARMC6 interacts with telomerase components, particularly human shelterin protein hTRF2, and participates in a telomerase interaction network 12. However, ARMC6 appears non-essential for canonical telomere maintenance, suggesting non-telomeric functions 1. Clinically, ARMC6 shows significant disease relevance in cancer contexts. In neuroblastoma, ARMC6 is a MYC target gene upregulated in MYCN-amplified cases and associates with poor prognosis 3. Dysregulation of ARMC6 methylation has been identified in schizophrenia patients with tardive dyskinesia, a movement disorder complication 4. Overexpression of ARMC6 alters expression of genes in oncogenic and non-canonical telomerase pathways 2. These findings suggest ARMC6 functions at the intersection of gene regulation and telomeric processes, with implications for cancer biology and neuropsychiatric disease.