ASB11 (ankyrin repeat and SOCS box containing 11) is a substrate-recognition component of cullin-5-RING E3 ubiquitin-protein ligase (CRL5) complexes that mediates ubiquitination and proteasomal degradation of target proteins including BIK, DIRAS2, RPN1, and PAICS 123. ASB11 functions as a regulator of the endoplasmic reticulum unfolded protein response by degrading BIK, with ER stress activating ASB11 through the IRE1α-XBP1s pathway to promote cell survival 2. The protein also regulates neural progenitor compartment size by maintaining neural precursors in a proliferating, undifferentiated state through control of SoxB1 transcription factors 4. Recently, ASB11 was identified as a critical driver of purinosome assembly through K6-polyubiquitination of PAICS, enhancing de novo purine synthesis and promoting melanoma cell proliferation and tumorigenesis 5. In pancreatic cancer, the UBE2F-CRL5ASB11 axis promotes KRAS-driven tumorigenesis via DIRAS2 degradation 3. ASB11 is also implicated in autism spectrum disorder susceptibility based on X-chrX-wide association studies 6. ASB11 undergoes FIH-catalyzed asparaginyl hydroxylation in ankyrin repeat motifs 7, potentially modulating its function in disease contexts.