ASB17 (ankyrin repeat and SOCS box containing 17) is a cytosolic protein that functions as a component of SCF-like E3 ubiquitin ligase complexes, but with distinct regulatory roles in inflammation and reproduction. In immune signaling, ASB17 promotes lipopolysaccharide-induced inflammation by stabilizing TRAF6 protein through inhibiting its K48-linked polyubiquitination, thereby facilitating NF-κB activation and enhancing pro-inflammatory cytokine expression including CCL2 and IL-6 1. The protein interacts with TRAF6's zinc finger domain via its amino acid 177-250 segment 1. ASB17 exhibits testis-enriched expression and has been classified as a cancer-testis gene that can be reactivated in colon cancer cells through epigenetic modifications using DNA methyltransferase and histone deacetylase inhibitors 2. However, ASB17 knockout mice show normal fertility and spermatogenesis, with only minor compensation effects when combined with ASB15 deletion 3. Clinical relevance includes potential involvement in male infertility, as chr1 translocations disrupting ASB17 have been associated with severe male infertility cases 4. The gene's dual roles in immune regulation and reproductive biology suggest tissue-specific functional contexts.