AVL9 (AVL9 cell migration associated) is a cytoplasmic protein that functions primarily in cell migration and intracellular trafficking. At the cellular level, AVL9 localizes to recycling endosomes and regulates cell migration through multiple mechanisms. In colorectal carcinoma, AVL9 promotes cell migration by regulating EGFR expression, with knockdown of EGFR restraining AVL9-induced migration 1. AVL9 also participates in intracellular trafficking and cell cycle progression 2, and can activate the cyclin-dependent kinase pathway to promote cell proliferation and invasion 3. AVL9 has significant disease relevance across multiple cancer types. In pancreatic ductal adenocarcinoma, hypoxia-driven AVL9 expression promotes chemoresistance by forming a complex with IκBα and SKP1, leading to NF-κB pathway activation 4. In non-small-cell lung cancer, the miR-203a-3p/AVL9 axis regulates cell proliferation, migration, and invasion, with high AVL9 expression correlating with poor prognosis 5. Similarly, in NSCLC, the hsa_circ_0058357/miR-24-3p/AVL9 axis promotes tumor progression 6. AVL9 overexpression is associated with poor prognosis in colorectal carcinoma, correlating with metastasis and advanced stages 1. Additionally, AVL9 was identified as a genomewide significant candidate gene linked to myopia in African American families 7, suggesting broader physiological roles beyond cancer.