1 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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17PubMed Papers
0Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
cytoplasm
DENND11 is a probable guanine nucleotide exchange factor (GEF) containing a DENN domain, likely functioning in the cytoplasm to promote GDP-to-GTP exchange on small GTPases. Based on limited published evidence, DENND11 (also designated LCHN) is induced in the hippocampus following transient cerebral ischemia 1. Overexpression of DENND11 promotes neuritogenesis, generating neurons with longer and more branched axons and dendrites 1, suggesting a role in neuronal recovery and structural reorganization following ischemic injury.
1
DENND11/LCHN is induced in rat hippocampus after transient forebrain ischemia and promotes neuritogenesis; overexpression increases axonal and dendritic branching, suggesting roles in neuronal recovery and restructuring
PMID: 17394467⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
No pathogenic variants reported on ClinVar for this gene.
No tissue expression data available for this gene.