BASP1 (brain abundant membrane attached signal protein 1) functions as a multifaceted regulatory protein with diverse roles in cellular processes and disease pathogenesis. The protein serves as a scaffold protein that is preferentially sorted into extracellular vesicles, enabling high-density surface display and luminal loading of therapeutic molecules 1. BASP1 acts as a transcriptional regulator through epigenetic mechanisms, where it can be recruited to promoter regions and influence gene expression through histone modifications. In gliomas, BASP1 downregulation promotes temozolomide resistance by removing repressive histone modifications and allowing activation of the FBXO32/NF-κB/MGMT axis 2. The protein plays a critical role in inflammatory signaling, particularly in myeloid cells where BASP1+ monocytes serve as first-line immune cells that infiltrate tissues during pathological conditions. Myeloid-specific BASP1 expression contributes to NASH pathogenesis by enhancing pro-inflammatory responses and NLRP3 inflammasome activation 3. In acute aortic dissection, BASP1+ monocytes promote vascular remodeling and inflammation through 'PIP2-SP1-ACTN1/VAV3' and 'ITGB1-Rac1-GSN' signaling pathways 4. Additionally, BASP1-AS1, a divergent long non-coding RNA, positively regulates stemness and pluripotency in neuroblastoma cells by controlling BASP1 expression and stem cell markers 5. In leukemia, increased BASP1 levels can repress oncogenic transcriptional networks when immunoproteasome function is disrupted 6.