BCAN (brevican) encodes a central nervous system proteoglycan that plays critical roles in brain structure and function. The protein is involved in stabilizing interactions between hyaluronan and brain proteoglycans, contributing to the formation of perineuronal nets and extracellular matrix organization 1. BCAN shows significant associations with brain aging, with lower plasma levels correlating with accelerated brain aging across multiple cortical and subcortical structures 2. The protein serves as a biomarker for various neurological conditions, including reduced risk of ischemic stroke, peripheral artery disease in type 2 diabetes, and depression 345. Functionally, BCAN appears to mediate cognitive performance, with plasma levels associated with digit symbol substitution test performance through structural brain phenotype pathways 6. Disease relevance includes a pathogenic mutation in the BCAN gene causing Episodic Falling syndrome in Cavalier King Charles spaniels, representing a paroxysmal movement disorder 7. The gene is located on chromosome 1-23, tandemly arranged with BRAL1 1. These findings highlight BCAN's importance in maintaining brain structure, cognitive function, and its potential as a therapeutic target for neurological disorders.