BDKRB1 encodes the bradykinin receptor B1, a G protein-coupled receptor with preferential affinity for kinin metabolites lacking the C-terminal arginine, such as des-Arg9-BK 1. The receptor is characterized by low basal expression but significant upregulation following tissue injury and inflammation 1. BDKRB1 is located on chromosome 14.1-q32.2 as a single-copy gene and shows widespread tissue distribution, with notable expression in kidney and pancreas 2. Mechanistically, BDKRB1 activation triggers calcium influx and activates downstream signaling pathways including MEK1-ERK1/2-NF-κB 3 and Ca2+/CaMKII/MEK1/ERK cascades 4. The receptor plays pathological roles in multiple diseases: it exacerbates sepsis by inducing neutrophil dysfunction and CXCR2 desensitization 5, promotes glioblastoma cell migration and invasion through AQP4 upregulation 3, and contributes to systemic sclerosis fibrosis through sCD13 signaling 6. BDKRB1 represents a promising therapeutic target, as antagonists improve outcomes in sepsis when combined with antibiotics 5 and show antifibrotic effects 6. The receptor is also being investigated as a target for novel analgesic development 7.