BICD2 (bicaudal D cargo adaptor 2) is a conserved adapter protein that links the dynein motor complex to various cargos and enhances dynein processivity in conjunction with dynactin 1. It stabilizes RAB6A in its GTP-bound form and regulates COPI-independent Golgi-endoplasmic reticulum (ER) transport through dynein-dynactin recruitment 2. BICD2 contributes to nuclear and centrosomal positioning during mitosis and facilitates viral and cellular cargo trafficking along microtubules 34. BICD2 variants cause spinal muscular atrophy with lower extremity predominance (SMALED2), exhibiting variable severity from childhood-onset to potentially lethal presentations 5. The gene is also implicated in distal hereditary motor neuropathies (dHMN), where BICD2 ranks among the most frequent causative genes 6. Recent evidence identifies BICD2 as a novel autosomal recessive candidate in familial dilated cardiomyopathy, with bicd2-knockout zebrafish showing cardiac dysfunction and altered mitochondrial energy metabolism 7. Additionally, BICD2 has emerged as a novel autoantibody target in systemic sclerosis-specific immune responses 8, and DNA hypermethylation of BICD2 serves as a potential biomarker for major depressive disorder, with functional implications for hippocampal BDNF signaling 9.