BICRA (BRD4 interacting chr19 remodeling complex associated protein) is a component of the SWI/SNF chr19 remodeling complex, specifically the non-canonical BAF (ncBAF) subcomplex 1. It functions as a transcriptional regulator that alters chr19 structure by modifying DNA-histone contacts within nucleosomes in an ATP-dependent manner, thereby promoting transcription by RNA polymerase II 2. BICRA physically interacts with other ncBAF complex members and serves as a defining component of this complex 1. Pathogenic variants in BICRA cause Coffin-Siris syndrome 12 (CSS12), a rare autosomal dominant neurodevelopmental disorder 134. Affected individuals exhibit developmental delay, intellectual disability, autism spectrum disorder, dysmorphic facial features, and behavioral abnormalities 1. Additional features include visual impairment, gastrointestinal dysfunction, growth retardation, and in adults, increased prevalence of obesity and scoliosis 53. Notably, BICRA-related CSS differs from other SWI/SNF-related intellectual disability disorders by typically lacking fifth digit/nail hypoplasia 1. Loss-of-function variants, including nonsense mutations causing premature termination, predominantly cause disease through haploinsufficiency 34. Additionally, BICRA variants have been identified in osteoarthritis genome-wide association studies and cervical cancer genomic analyses, suggesting broader biological roles 67.