BIRC7 (baculoviral IAP repeat containing 7) is a member of the inhibitor of apoptosis protein (IAP) family that functions primarily as an anti-apoptotic regulator and E3 ubiquitin ligase 1. The protein blocks etoposide-induced apoptosis and protects cells against natural killer cell-mediated killing through its cysteine-type endopeptidase inhibitor activity 2. BIRC7 demonstrates ubiquitin-protein transferase activity and RING domain-containing E3 ubiquitin ligase function, potentially involved in protein degradation pathways 1. In cancer contexts, BIRC7 promotes tumor progression through multiple mechanisms: it enhances epithelial-mesenchymal transition and metastasis by suppressing autophagy via downregulation of ATG5 and BECN1 3, and its overexpression correlates with aggressive tumor characteristics including lymph node metastasis, tissue invasion, and advanced TNM staging across multiple cancer types 456. BIRC7 expression serves as an independent poor prognostic factor in pancreatic ductal adenocarcinoma, gallbladder cancer, and extrahepatic cholangiocarcinoma 564. During development, BIRC7 exhibits tissue-specific expression patterns, functioning as a late fiber gene in lens development where it may contribute to organelle degradation processes 1, and shows altered expression in gestational diabetes mellitus affecting placental apoptosis 7.