BIVM-ERCC5 is a readthrough transcript located on chromosome 13 with potential roles in DNA repair and cancer-related pathways. The gene appears to function within nucleotide excision repair (NER) pathway mechanisms, as it was identified among NER pathway genes associated with disease susceptibility 1. A genetic variant (rs1323697_C) in BIVM-ERCC5 was significantly associated with increased breast cancer risk (OR = 1.06, 95% CI = 1.03-1.10) in a large meta-analysis of 53,107 European-descent subjects 1. Functional analysis revealed that the risk allele correlates with elevated mRNA expression levels in lymphoblastoid cell lines (p = 0.022), suggesting the variant modulates gene expression 1. In colorectal cancer models, BIVM-ERCC5 expression was upregulated following sporamin treatment, a compound that promotes DNA damage repair pathways 2. Additionally, BIVM-ERCC5 was identified as a differentially expressed gene in esophageal squamous cell carcinoma comparing responders to non-responders of neoadjuvant immunochemotherapy 3. These findings suggest BIVM-ERCC5 participates in DNA repair mechanisms and may influence cancer susceptibility and treatment response, though specific molecular mechanisms require further investigation.