BIVM (basic, immunoglobulin-like variable motif containing) is a housekeeping gene located on chromosome 13-q33 that encodes a 503-amino-acid protein with predicted basic properties (pI 9.1) 1. The gene is highly conserved throughout deuterostomes and features an immunoglobulin-like variable motif in its sequence 1. BIVM is widely expressed in normal tissues and shows ubiquitous expression patterns consistent with housekeeping gene function 1. Based on Gene Ontology annotations and supporting evidence, BIVM localizes to the nucleus and nucleoplasm, with predicted roles in protein binding and DNA endonuclease activity. Functionally, BIVM has been identified as a ciliary gene through phylogenetic profiling and its localization was experimentally confirmed in cilia/basal bodies 2, suggesting involvement in ciliary structure and function. In disease contexts, BIVM mutations associate with bronchopulmonary dysplasia (BPD) in preterm infants, with the rs3825519 variant potentially affecting cilia movement and ventilator dependency 3. Additionally, the BIVM-ERCC5 region harbors SNPs associated with breast cancer risk through nucleotide excision repair pathway involvement 4, and BIVM expression changes occur in colorectal cancer treated with anti-cancer compounds 5. BIVM also shows differential expression in pesticide-induced Parkinson's disease models 6.