2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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9PubMed Papers
8Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Swiss-Prot Reviewed
lipid bindingextracellular regionmetabolic syndromebreast carcinomacarcinoma of liver and intrahepatic biliary tractneoplasm
Based on limited published evidence, BPIFA3 is a BPI fold-containing protein located on chromosome 20.21. Genome-wide association studies have identified BPIFA3 as associated with skin aging phenotypes, with a combined odds ratio of 1.859 [95% CI: 1.567-2.151] across multiple studies 1. Additionally, BPIFA3 was identified as a top candidate gene in a genome-wide association study of otitis media susceptibility in childhood 2, suggesting potential roles in immune or inflammatory responses. However, functional characterization remains limited.
1
BPIFA3 associated with skin aging phenotypes with OR 1.859 [1.567-2.151] in meta-analysis of GWAS and candidate gene studies
PMID: 399230552
BPIFA3 identified as top gene-based hit (P=2×10⁻⁵) in GWAS of otitis media susceptibility in childhood
PMID: 23133572⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
metabolic syndromeOpen Targets
breast carcinomaOpen Targets
carcinoma of liver and intrahepatic biliary tractOpen Targets
diabetes mellitusOpen Targets
No pathogenic variants reported on ClinVar for this gene.