BPIFB6 is an endoplasmic reticulum (ER)-localized protein belonging to the BPI fold-containing family that functions as a positive regulator of enterovirus replication 1. Mechanistically, BPIFB6 controls secretory pathway trafficking and maintains Golgi complex morphology; loss of BPIFB6 expression induces pronounced alterations in retrograde and anterograde trafficking, leading to Golgi fragmentation 1. BPIFB6 silencing dramatically suppresses replication of multiple enteroviruses including coxsackievirus B, poliovirus, and enterovirus 71 in a pan-viral manner 1. Beyond viral regulation, BPIFB6 has been identified as a novel genetic biomarker influencing blood low-density lipoprotein cholesterol (LDL-C) levels, with a putative role in lipid binding and transport 2. The gene belongs to the lipid transfer/lipopolysaccharide binding protein family, structurally related proteins capable of binding phospholipids 3. Clinically, BPIFB6 represents a potential therapeutic target for enterovirus infections associated with severe pathologies including aseptic meningitis, dilated cardiomyopathy, and type I diabetes 1, while its involvement in lipid metabolism suggests potential relevance to cardiovascular disease prevention strategies 2.