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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
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BPY2C
basic charge Y-linked 2C
Chromosome Y Β· Yq11.23
NCBI Gene: 442868Ensembl: ENSG00000183753.10HGNC: HGNC:13508UniProt: O14599
8PubMed Papers
5Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Swiss-Prot Reviewed
male infertilityhepatocellular carcinomainfertilityazoospermia
✦AI Summary

Based on limited published evidence, BPY2C is a Y-linked gene with a basic charge domain. In hepatocellular carcinoma (HCC), BPY2C expression is regulated by the AC006262.5-miR-7855-5p axis, where the long non-coding RNA AC006262.5 suppresses tumor-suppressive miR-7855-5p, thereby facilitating BPY2C expression 1. This regulatory pathway promotes HCC cell proliferation, migration, and invasiveness, suggesting BPY2C involvement in cancer progression. The specific molecular function of BPY2C protein remains to be characterized.

Sources cited
1
BPY2C is regulated by the AC006262.5-miR-7855-5p axis and involved in promoting hepatocellular carcinoma proliferation, migration, and invasiveness
PMID: 32956593
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜5
male infertilityOpen Targets
0.01Suggestive
hepatocellular carcinomaOpen Targets
0.01Suggestive
infertilityOpen Targets
0.01Suggestive
azoospermiaOpen Targets
0.00Suggestive
non-small cell lung carcinomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
UTYProtein interaction97%CDY1BProtein interaction97%USP9YProtein interaction94%DDX3YProtein interaction94%DAZ4Protein interaction94%RBMY1FProtein interaction94%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
Click a node to explore
BPY2CUTYCDY1BUSP9YDDX3YDAZ4RBMY1F
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt O14599
View on AlphaFold β†—
RankingsWhere BPY2C stands among ~20K protein-coding genes
  • #17,541of 20,598
    Most Researched8
Genes detectedBPY2C
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
The AC006262.5-miR-7855-5p-BPY2C axis facilitates hepatocellular carcinoma proliferation and migration.
PMID: 32956593
Biochem Cell Biol Β· 2021
1.00