BRPF1 (bromodomain and PHD finger containing 1) is a scaffold subunit of histone acetyltransferase (HAT) complexes, including MOZ/MORF and HBO1 complexes, that catalyze histone H3 acetylation 1. As a core component of these multi-subunit complexes, BRPF1 directs KAT7/HBO1 specificity toward histone H3 lysine-14 acetylation (H3K14ac) and facilitates H3K23 acetylation 2. BRPF1 contains multiple histone-binding domains (bromodomain, PHD fingers, and PWWP modules) that enable recognition of specific histone modifications and coordinate epigenetic crosstalk 3. In human embryonic stem cells, BRPF1 bridges H3K4me3 and H3K23ac modifications at stemness genes and is essential for maintaining pluripotency 3. Beyond histone modifications, BRPF1 positively regulates transcription of developmental genes including RUNX1 and RUNX2 2. Pathogenic BRPF1 variants cause autosomal dominant Intellectual Developmental Disorder with Dysmorphic Facies and Ptosis (IDDDFP), characterized by developmental delay, intellectual disability, and distinctive facial features including ptosis and blepharophimosis 4. Disease-associated variants impair H3K23 propionylation and active chr3 maintenance 5. Additionally, BRPF1-KAT6A/KAT6B complexes are implicated in cancer development, with somatic mutations found in leukemia and medulloblastoma 1, and BRPF1 serves as a therapeutic target in NUP98-rearranged acute myeloid leukemia 6.