CACNA2D1 encodes the α2/δ-1 auxiliary subunit of voltage-gated calcium channels, which regulates calcium current density and activation/inactivation kinetics of the pore-forming channel 1. The protein plays a critical role in excitation-contraction coupling and cardiac electrophysiology by facilitating NMDAR trafficking and synaptic targeting in neuronal tissues 2. Assembly of CACNA2D1 with the channel complex requires endoplasmic reticulum-resident chaperone proteins, with EMC hand-off to α2/δ-1 being essential for proper channel biogenesis and function 3. Beyond its canonical role in calcium signaling, CACNA2D1 acts as an oncogene in multiple cancers: it promotes colon cancer progression through fibroblast regulation and epithelial-mesenchymal transition pathways 4, and similarly drives gastric cancer growth via p53-dependent apoptosis suppression 5. CACNA2D1 is also implicated in developmental epileptic encephalopathy and intellectual disability through gain-of-function mechanisms 6, cardiac arrhythmias 7, and vascular smooth muscle dysfunction in abdominal aortic aneurysm 8. Additionally, CACNA2D1 expression is upregulated in gestational diabetes mellitus through histone lactylation modification and promotes cellular proliferation 9. These findings establish CACNA2D1 as a multifunctional protein with therapeutic potential as both a drug target and biomarker across neurological, cardiac, metabolic, and oncological disease contexts.