CACNG6 encodes calcium voltage-gated channel auxiliary subunit gamma 6, which regulates L-type calcium channels containing CACNA1C as the pore-forming subunit 1. The protein stabilizes calcium channel function and modulates calcium ion transmembrane transport critical for cellular processes. CACNG6 has been implicated in multiple disease contexts. Genetic variants in CACNG6 are associated with aspirin-intolerant asthma (AIA), with the rs192808C>T polymorphism showing significant association (OR=2.88-2.99) 1. Mendelian randomization analysis identified CACNG6 among 35 druggable genes causally linked to childhood asthma susceptibility 2. Epistatic interactions between CACNG6 and CACNG5 variants suggest biological crosstalk contributing to schizophrenia risk 3. In acute myocardial infarction, CACNG6 expression tends to be downregulated in affected blood samples 4. Recent evidence indicates CACNG6 downregulation inhibits calcium ion influx and modulates the MAPK pathway in antimicrobial responses 5. Downregulation of CACNG6 is associated with increased pain interference during chemotherapy in colorectal cancer patients 6. These findings suggest CACNG6 represents a potential therapeutic target for airway inflammatory diseases and cancer-related symptom management.