CACUL1 (CDK2 associated cullin domain 1) is a multifunctional regulatory protein that promotes cell proliferation through cell cycle control and modulates various signaling pathways. CACUL1 promotes cell proliferation by facilitating G1/S phase transition through activation of CDK2 and regulation of cyclins 1. The protein functions as a key epigenetic regulator by interacting with chr10-modifying enzymes, including direct binding to SIRT1 and competing with LSD1 for target interactions, thereby controlling histone modifications and gene transcription 23. CACUL1 negatively regulates tumor suppressor pathways by attenuating p53 activity through inhibition of PML SUMOylation 4 and suppressing androgen receptor transcriptional activity in prostate cancer 3. Additionally, CACUL1 stabilizes Nrf2 by interfering with the Cul3-Keap1 ubiquitination complex, enhancing cellular antioxidant responses 5. In cancer contexts, CACUL1 expression is elevated in gastric cancer tissues and promotes tumor invasion and metastasis through MMP9 and Slug pathways 67. The protein also inhibits adipogenesis by repressing PPARγ signaling 2. These diverse functions position CACUL1 as both an oncogenic factor in various cancers and a potential therapeutic target.