CALHM6 (calcium homeostasis modulator family member 6) encodes a pore-forming subunit of an ATP-permeable channel that plays a critical role in immune regulation 1. The protein assembles into gap junction-like structures with conical pore geometry, where lipid distribution and voltage regulation control channel function 1. CALHM6 is implicated in immune response modulation, particularly in regulating cellular immunity to infection 2. Genome-wide association studies (GWAS) have identified CALHM6 as a susceptibility locus for steroid-sensitive nephrotic syndrome (SSNS), the most common childhood glomerular disease 23. The risk allele at rs2637678 is associated with lower lymphocytic CALHM6 expression, suggesting that reduced CALHM6 expression contributes to immune dysregulation in SSNS pathogenesis 2. CALHM6 has also been associated with ulcerative colitis, where it is selectively upregulated in inflamed colonic mucosa 4. Additionally, CALHM6 expression is significantly downregulated during hepatitis B virus infection and may serve as an early predictive marker 5. In pediatric acute myeloid leukemia, FAM26F/CALHM6 represents a prognostically significant gene in immune cell interaction pathways 6. These findings collectively indicate that CALHM6 functions as an immunomodulatory protein whose dysregulation contributes to multiple inflammatory and immune-mediated diseases.