TMEM150C (Tentonin3) is a pore-forming subunit of a mechanically activated (MA) cation channel with high calcium permeability 1. The protein functions as a tetrameric structure with six transmembrane helices forming an inter-subunit pore, displaying slow inactivation kinetics that distinguish it from PIEZO1 channels 1. TMEM150C is expressed in sensory neurons including nociceptors, mechanoreceptors, and proprioceptors, with immunodetection in human dorsal root ganglia (41% of neurons), cutaneous sensory corpuscles (Meissner, Pacinian, and Ruffini), and muscle spindles 2. Beyond its primary mechanotransduction role, TMEM150C functions as a regulator of other mechano-gated channels (PIEZO1, PIEZO2, TREK-1), prolonging mechano-current duration and modulating activation thresholds 3. In the brain, TMEM150C expression correlates with viscoelastic properties in white matter and the pons, suggesting region-specific mechanotransduction roles 4. Additionally, TMEM150C/DRAM4 functions in nutrient-responsive autophagy regulation, modulating autophagic flux under nutrient-deprivation 5. Dysregulation has been associated with diabetic nephropathy as a potential biomarker 6, and the channel family represents a therapeutic target for mechanopathologies 7.