CAMK4 (calcium/calmodulin-dependent protein kinase IV) is a versatile serine/threonine kinase that integrates calcium signaling into immune and neuronal functions 1. The kinase operates downstream of calcium/calmodulin activation to phosphorylate transcription factors including CREB1, MEF2D, and JUN, thereby regulating gene expression critical for immune responses and neuronal plasticity 2. In immune cells, CAMK4 promotes T-cell differentiation and IL-17 production in Th17 cells, with dysregulation implicated in autoimmune diseases including systemic lupus erythematosus 2. CAMK4 also regulates macrophage and keratinocyte function; deletion of Camk4 reduces psoriatic inflammation by enhancing IL-10 production and limiting pro-inflammatory gene expression 3. In the nervous system, CAMK4 contributes to synaptic plasticity and memory consolidation through calcium-dependent signaling pathways 1. Emerging evidence identifies CAMK4 as a convergence point for autism spectrum disorder pathogenesis, with both direct genetic variants and indirect effects through autism-associated genes disrupting CaMK4 signaling 4. Additionally, CAMK4 shows epigenetic regulation in skeletal muscle, maintaining hypomethylation signatures associated with muscle hypertrophy memory 5. These findings establish CAMK4 as a potential therapeutic target in autoimmune, inflammatory, neuropsychiatric, and muscle-related diseases.