CAMKK1 (calcium/calmodulin-dependent protein kinase kinase 1) is a serine/threonine kinase that functions as an upstream activator in calcium-triggered signaling cascades 1. The protein phosphorylates downstream targets including CAMK1, CAMK4, and AKT1, thereby regulating cellular processes spanning energy homeostasis, apoptosis, and bone metabolism 2. CAMKK1 operates primarily through AMPK-dependent mechanisms to regulate lipid metabolism; exosomal CAMKK1 transferred to hepatocytes activates AMPK, subsequently promoting fatty acid oxidation via PPARα signaling while inhibiting lipogenesis through SREBP-1C suppression 3. In metabolic disease, CAMKK1 is elevated in type 2 diabetes patients and shows positive associations with AMPK and inflammatory markers (TNFα) 2. The common SNP rs7214723 (E375G substitution in the kinase domain) is associated with both enhanced lung cancer prognosis and altered cancer risk, with the T allele conferring increased lung cancer susceptibility in Chinese populations 45. Additionally, Nrf2-mediated regulation of CAMKK1 controls osteoclast differentiation and bone loss in parasitic infection contexts 6. These findings establish CAMKK1 as a multifunctional regulator with therapeutic potential in metabolic and neoplastic diseases.