CAMSAP2 is a key microtubule-organizing protein that specifically binds and stabilizes minus-ends of non-centrosomal microtubules, playing crucial roles in cellular organization and pathological processes. CAMSAP2 recognizes growing microtubule minus-ends, decorates and stabilizes microtubule lattices, and protects minus-ends from depolymerization while reducing polymerization velocity 1. The protein is essential for neuronal development, where it localizes to non-centrosomal microtubule minus-ends and requires protection by WDR47 from katanin-mediated severing 1. CAMSAP2 cooperates with EB1 to regulate microtubule dynamics and enables proper autophagosome transport through microtubule networks 2. In mitosis, CAMSAP2 is required for bridging fiber assembly, ensuring proper spindle formation and chromosome 1 3. Clinically, CAMSAP2 has significant oncogenic roles across multiple cancer types. In hepatocellular carcinoma, CAMSAP2 upregulation correlates with poor prognosis and drives metastasis through noncentrosomal microtubule acetylation via c-Jun/HDAC6 signaling 4. Similarly, in lung cancer, CAMSAP2 enhances metastasis by mediating RASAL2 degradation and activating ERK signaling 5, while in gastric cancer, it promotes invasion through TGF-β pathway upregulation 6. CAMSAP2 is also important for endothelial cell polarity and angiogenesis 7.