CBX8 — chromobox 8

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

106PubMed Papers

#4,502 · top 23% of 19K genes

20Diseases

top 38%

0Drugs

0Pathogenic Variants

Hub GeneExperimental GO EvidenceSwiss-Prot Reviewed

negative regulation of transcription by RNA polymerase IIchromatinhistone H3K27me3 reader activitynucleusatrial fibrillationrisk-taking behavioursmoking initiationbreast carcinoma

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

chromobox 8

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

atrial fibrillationOpen Targets

0.48Moderate

risk-taking behaviourOpen Targets

0.43Moderate

smoking initiationOpen Targets

0.40Moderate

breast carcinomaOpen Targets

0.39Weak

attention deficit hyperactivity disorderOpen Targets

0.32Weak

substance abuseOpen Targets

0.32Weak

smoking behaviorOpen Targets

0.29Weak

Abnormality of the skeletal systemOpen Targets

0.28Weak

breast cancerOpen Targets

0.23Weak

spastic cerebral palsyOpen Targets

0.12Weak

neoplasmOpen Targets

0.11Weak

hepatocellular carcinomaOpen Targets

0.10Weak

colorectal carcinomaOpen Targets

0.10Weak

glioblastoma multiformeOpen Targets

0.09Suggestive

esophageal squamous cell carcinomaOpen Targets

0.08Suggestive

cervical cancerOpen Targets

0.08Suggestive

laryngeal squamous cell carcinomaOpen Targets

0.08Suggestive

pachyonychia congenitaOpen Targets

0.07Suggestive

cancerOpen Targets

0.06Suggestive

gliomaOpen Targets

0.04Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Liver

100%

Brain

85%

Bone Marrow

75%

Heart

65%

Lung

53%

Ovary

38%

Gene Interaction Network6 neighbors

Click a node to explore

Structure3 PDB hits

Preparing viewer…

PDB5EQ0 · 1.18 Å · X-ray

View on RCSB

ConstraintgnomAD v4.1

LOEUFⓘ

0.43Moderately Constrained

pLIⓘ

1.00Intolerant

Observed/Expected LoF0.24 [0.14–0.43]

Rankings2 dim

Where CBX8 stands among ~20K protein-coding genes

#4,468of 20,598
Most Researched106 · top quartile
#2,291of 17,882
Most Constrained (LOEUF)0.43 · top quartile

Meta

Genes detectedCBX8

Sources retrieved5 papers

Response time—

Sources5

The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

PMID: 12167701

Mol Cell Biol · 2002

0.95

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

PMID: 12477932

Proc Natl Acad Sci U S A · 2002

0.95

The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3.

PMID: 11313972

Oncogene · 2001

0.95

The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias.

PMID: 11439343

Oncogene · 2001

0.95

HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties.

PMID: 10825164

J Biol Chem · 2000

0.95

View all 106 papers on PubMed →

Loading gene record…

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

106PubMed Papers

#4,502 · top 23% of 19K genes

20Diseases

top 38%

0Drugs

0Pathogenic Variants

Hub GeneExperimental GO EvidenceSwiss-Prot Reviewed

negative regulation of transcription by RNA polymerase IIchromatinhistone H3K27me3 reader activitynucleusatrial fibrillationrisk-taking behavioursmoking initiationbreast carcinoma

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

chromobox 8

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

atrial fibrillationOpen Targets

0.48Moderate

risk-taking behaviourOpen Targets

0.43Moderate

smoking initiationOpen Targets

0.40Moderate

breast carcinomaOpen Targets

0.39Weak

attention deficit hyperactivity disorderOpen Targets

0.32Weak

substance abuseOpen Targets

0.32Weak

smoking behaviorOpen Targets

0.29Weak

Abnormality of the skeletal systemOpen Targets

0.28Weak

breast cancerOpen Targets

0.23Weak

spastic cerebral palsyOpen Targets

0.12Weak

neoplasmOpen Targets

0.11Weak

hepatocellular carcinomaOpen Targets

0.10Weak

colorectal carcinomaOpen Targets

0.10Weak

glioblastoma multiformeOpen Targets

0.09Suggestive

esophageal squamous cell carcinomaOpen Targets

0.08Suggestive

cervical cancerOpen Targets

0.08Suggestive

laryngeal squamous cell carcinomaOpen Targets

0.08Suggestive

pachyonychia congenitaOpen Targets

0.07Suggestive

cancerOpen Targets

0.06Suggestive

gliomaOpen Targets

0.04Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Liver

100%

Brain

85%

Bone Marrow

75%

Heart

65%

Lung

53%

Ovary

38%

Gene Interaction Network6 neighbors

Click a node to explore

Structure3 PDB hits

Preparing viewer…

PDB5EQ0 · 1.18 Å · X-ray

View on RCSB

ConstraintgnomAD v4.1

LOEUFⓘ

0.43Moderately Constrained

pLIⓘ

1.00Intolerant

Observed/Expected LoF0.24 [0.14–0.43]

Rankings2 dim

Where CBX8 stands among ~20K protein-coding genes

#4,468of 20,598
Most Researched106 · top quartile
#2,291of 17,882
Most Constrained (LOEUF)0.43 · top quartile