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GeneE
0 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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CBX8
chromobox 8
Chromosome 17 · 17q25.3
NCBI Gene: 57332Ensembl: ENSG00000141570.11HGNC: HGNC:15962UniProt: Q9HC52
106PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Hub GeneTranscription Factor
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
negative regulation of transcription by RNA polymerase IIchromatinhistone H3K27me3 reader activitynucleusatrial fibrillationrisk-taking behavioursmoking initiationbreast carcinoma
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

chromobox 8

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
atrial fibrillationOpen Targets
0.48Moderate
risk-taking behaviourOpen Targets
0.43Moderate
smoking initiationOpen Targets
0.40Moderate
breast carcinomaOpen Targets
0.39Weak
attention deficit hyperactivity disorderOpen Targets
0.32Weak
substance abuseOpen Targets
0.32Weak
smoking behaviorOpen Targets
0.29Weak
Abnormality of the skeletal systemOpen Targets
0.28Weak
breast cancerOpen Targets
0.23Weak
spastic cerebral palsyOpen Targets
0.12Weak
neoplasmOpen Targets
0.11Weak
hepatocellular carcinomaOpen Targets
0.10Weak
colorectal carcinomaOpen Targets
0.10Weak
glioblastoma multiformeOpen Targets
0.09Suggestive
esophageal squamous cell carcinomaOpen Targets
0.08Suggestive
cervical cancerOpen Targets
0.08Suggestive
laryngeal squamous cell carcinomaOpen Targets
0.08Suggestive
pachyonychia congenitaOpen Targets
0.07Suggestive
cancerOpen Targets
0.06Suggestive
gliomaOpen Targets
0.04Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
CDC27Protein interaction100%CDC23Protein interaction100%CDC16Protein interaction100%ANAPC10Protein interaction100%SCMH1Protein interaction100%UBE2SProtein interaction100%
Tissue Expression6 tissues
Liver
100%
Brain
85%
Bone Marrow
75%
Heart
65%
Lung
53%
Ovary
38%
Gene Interaction Network
Click a node to explore
CBX8CDC27CDC23CDC16ANAPC10SCMH1UBE2S
PROTEIN STRUCTURE
Preparing viewer…
PDB5EQ0 · 1.18 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
0.43Moderately Constrained
pLIⓘ
1.00Intolerant
Observed/Expected LoF0.24 [0.14–0.43]
RankingsWhere CBX8 stands among ~20K protein-coding genes
  • #4,468of 20,598
    Most Researched106 · top quartile
  • #2,291of 17,882
    Most Constrained (LOEUF)0.43 · top quartile
Genes detectedCBX8
Sources retrieved0 papers
Response time—