CC2D1A (coiled-coil and C2 domain containing 1A) is a multifunctional scaffold protein that plays critical roles in neurodevelopment and cellular signaling. The protein functions as a transcriptional repressor of the HTR1A (serotonin-1A receptor) gene, binding to specific DNA elements and mediating calcium-dependent regulation of transcription 1. CC2D1A exhibits diverse subcellular localizations with distinct functions: when nuclear, it acts as a transcriptional repressor; when cytoplasmic, it serves as a scaffold in PI3K/AKT signaling pathways; and in centrosomes, it regulates spindle pole organization during mitosis. Recent studies have revealed a crucial role in ciliogenesis, with CC2D1A expression in ciliated tissues including the brain's ventricular zone, kidney, and left-right organizer 2. Loss of CC2D1A function disrupts primary cilia formation and cerebrospinal fluid circulation 2. The protein also regulates NF-κB signaling homeostasis, with both gain and loss of function increasing NF-κB activation 3. Proteomic analyses identify CC2D1A as uniquely enriched in postsynaptic compartments, interacting with proteins involved in RNA regulation and synaptic function 4. Biallelic loss-of-function mutations cause autosomal recessive intellectual disability, often accompanied by autism spectrum disorder, seizures, and heterotaxy 35, highlighting its essential role in neurodevelopmental processes.