CHMP6 (charged multivesicular body protein 6) is a core component of the ESCRT-III complex that plays critical roles in membrane remodeling and cellular homeostasis 1. As an N-myristoylated protein, CHMP6 functions as an acceptor for ESCRT-II components on endosomal membranes and regulates endosomal cargo sorting, including transferrin receptors and ubiquitinated proteins 1. The protein directly interacts with other ESCRT components including CHMP4b and EAP20 through its N-terminal basic domain 1. Beyond endosomal sorting, CHMP6 serves as a membrane repair mechanism that blocks ferroptosis by accumulating at the plasma membrane in response to lipid peroxidation triggers like erastin and RSL3 2. This anti-ferroptotic function involves calcium influx and endoplasmic reticulum stress pathways 2. CHMP6 has significant disease relevance, functioning as a tumor suppressor in colorectal cancer where it inhibits proliferation, migration, and invasion while enhancing anti-tumor immunity 3. Conversely, in melanoma, CHMP6 is upregulated by transcription factor ELK4 and promotes malignant properties while inhibiting ferroptosis 4. The protein also facilitates viral budding processes, as demonstrated with Oropouche virus glycoprotein secretion 5. These diverse functions highlight CHMP6's central role in membrane dynamics and cellular fate determination.