I cannot provide an accurate gene function summary for HGS (hepatocyte growth factor-regulated tyrosine kinase substrate) based on the provided PubMed abstracts. The abstracts in this collection exclusively address handgrip strength (HGS) measurements in clinical and epidemiological contexts, not the HGS gene protein. Topics covered include handgrip strength's relationship to cardiovascular disease risk 1, neurodegenerative disorders 2, motoric cognitive risk syndrome 3, hip fracture risk 4, and sport performance 5, along with reference values for healthy adults 6. One abstract addresses high-grade spondylolisthesis 7, and another discusses human gastruloid development 8, neither relevant to the HGS gene. To write an evidence-based gene function summary grounded in PubMed literature as required, abstracts directly addressing HGS protein function, mechanism, cellular localization, signal transduction roles, or disease associations would be necessary.