CCDC112 (coiled-coil domain containing 112) is a centriolar satellite protein with emerging roles in male reproductive biology and disease pathogenesis. In testicular tissue, CCDC112 functions as a stage-specific marker gene during human spermatogenesis, with expression patterns characteristic of germ cell development 1. The protein localizes to centriolar satellites and is hypothesized to participate in ciliogenesis and flagellum formation in germ cells, processes essential for spermatozoon maturation 2. Beyond reproductive function, CCDC112 has been identified as a prognostic biomarker in hepatocellular carcinoma (HCC), where it was selected among five differentially expressed genes to construct a risk stratification model with strong predictive performance for overall survival and immune cell infiltration patterns 3. Additionally, CCDC112 expression levels are significantly correlated with SARS-CoV-2 infection severity and HCC prognosis, suggesting involvement in immune response pathways, particularly T cell differentiation and monocyte function 4. While mechanistic details remain incompletely characterized, CCDC112's involvement in both reproductive development and cancer-related immune signaling positions it as a functionally important protein warranting further investigation in reproductive disorders and HCC immunotherapy applications.