TEX9 (testis expressed 9) is a centriolar satellite protein involved in ciliogenesis and flagellum formation in male germ cells 1. Phylogenetic profiling across 100 eukaryotic species predicted TEX9 as a ciliary gene candidate, with experimental confirmation of its cilia/basal body localization 2. In testis, TEX9 functions through protein-binding interactions at centriolar satellites, which are critical structures for ciliary assembly. Regarding disease relevance, comprehensive exome screening of 1,305 men showed that TEX9 knockdown in Drosophila resulted in normal fertility, suggesting it is not a major driver of male infertility despite its testis expression 3. However, TEX9 has emerged as significant in cancer biology: in triple-negative breast cancer, TEX9 was identified as a tumor cell-based regulator of immune rejection with previously unknown immune functions 4. In esophageal squamous cell carcinoma, TEX9 and eIF3b functionally synergize to promote cancer progression through AKT signaling pathway activation, enhancing proliferation and migration while inhibiting apoptosis 5. Clinically, TEX9's role in immune evasion and cancer progression suggests potential as a therapeutic target in immunotherapy-resistant cancers, though its primary reproductive function remains incompletely characterized.