CCDC22 is a key scaffolding subunit of the CCC (CCDC22/CCDC93/COMMD) complex, which is essential for endosomal recycling of transmembrane proteins back to the cell surface 1. The protein forms a coiled-coil structure that connects the CCC assembly with the Retriever complex (VPS35L, VPS26C, VPS29) to create the complete Commander complex, a 16-protein assembly involved in endosomal cargo retrieval 1. CCDC22 stabilizes a hetero-decameric ring of COMMD proteins through extensive interactions and recruits DENND10 to complete the complex 1. This machinery prevents lysosomal degradation and promotes recycling of over 120 cell surface proteins, including integrins, signaling receptors, and solute transporters 2. The Commander complex also regulates lysosomal homeostasis and has been implicated in Parkinson's disease risk 3. Mutations in CCDC22 cause X-linked Ritscher-Schinzel syndrome 2, a rare developmental disorder characterized by craniofacial dysmorphism, cerebellar malformations, cardiovascular defects, and intellectual disability 4. Specific missense mutations that disrupt COMMD protein binding result in attenuated forms of the syndrome without cardiac or neuroanatomical abnormalities 5. The complex also plays roles in cilium assembly, centrosome function, and copper homeostasis 6.