COMMD10 (COMM domain containing 10) is a scaffold protein that functions as a critical component of the Commander complex, which is essential for endosomal recycling of transmembrane cargos 1. The Commander complex comprises two sub-assemblies: the Retriever complex and the CCC complex, with COMMD10 being part of a distinctive hetero-decameric ring formed by COMMD1-COMMD10 proteins 1. Beyond its trafficking role, COMMD10 serves as a tumor suppressor that inhibits NF-κB signaling by preventing p65 nuclear translocation through direct binding to the Rel homology domain of p65, thereby promoting apoptosis and suppressing cell proliferation 23. COMMD10 also regulates copper-iron homeostasis and enhances ferroptosis by disrupting the HIF1α/ceruloplasmin feedback loop, which contributes to radiosensitivity in hepatocellular carcinoma 4. During embryogenesis, COMMD10 is essential for neural plate development, with knockout embryos displaying stalled development by E8.5 due to impaired neural crest formation and reduced Sox10 expression 5. Clinically, COMMD10 downregulation is associated with poor prognosis in gastric cancer and hepatocellular carcinoma, and the protein shows potential as a prognostic biomarker 62. The protein is subject to proteasomal degradation by FMNL2, which destabilizes COMMD10 to activate pro-metastatic NF-κB signaling in colorectal cancer 3.