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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
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COMMD8
COMM domain containing 8
Chromosome 4 Β· 4p12
NCBI Gene: 54951Ensembl: ENSG00000169019.12HGNC: HGNC:26036UniProt: Q9NX08
40PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transcription Factor
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingnucleoplasmprotein-containing complexcytosolneurodegenerative diseaseHydrocephalushemolytic anemialagophthalmos
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

COMM domain containing 8

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
neurodegenerative diseaseOpen Targets
0.45Moderate
HydrocephalusOpen Targets
0.33Weak
hemolytic anemiaOpen Targets
0.30Weak
lagophthalmosOpen Targets
0.12Weak
skull disorderOpen Targets
0.10Suggestive
hypopituitarismOpen Targets
0.10Suggestive
duodenal ulcerOpen Targets
0.10Suggestive
liver diseaseOpen Targets
0.08Suggestive
vascular diseaseOpen Targets
0.08Suggestive
risk-taking behaviourOpen Targets
0.08Suggestive
sleep apneaOpen Targets
0.07Suggestive
Abruptio PlacentaeOpen Targets
0.06Suggestive
non-small cell lung carcinomaOpen Targets
0.05Suggestive
preeclampsiaOpen Targets
0.05Suggestive
frozen shoulderOpen Targets
0.04Suggestive
nervous system benign neoplasmOpen Targets
0.04Suggestive
schizophreniaOpen Targets
0.03Suggestive
parasitic infectionOpen Targets
0.03Suggestive
neoplasmOpen Targets
0.02Suggestive
hepatocellular carcinomaOpen Targets
0.02Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
ANKRD50Shared pathway100%COMMD9Protein interaction97%COMMD6Protein interaction97%TFDP1Protein interaction96%COMMD5Protein interaction87%COMMD2Protein interaction87%
Tissue Expression6 tissues
Heart
100%
Bone Marrow
91%
Liver
37%
Lung
33%
Brain
31%
Ovary
24%
Gene Interaction Network
Click a node to explore
COMMD8ANKRD50COMMD9COMMD6TFDP1COMMD5COMMD2
PROTEIN STRUCTURE
Preparing viewer…
PDB8P0W Β· 2.90 Γ… Β· EM
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
1.37LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.86 [0.56–1.37]
RankingsWhere COMMD8 stands among ~20K protein-coding genes
  • #10,150of 20,598
    Most Researched40
  • #14,275of 17,882
    Most Constrained (LOEUF)1.37
Genes detectedCOMMD8
Sources retrieved0 papers
Response timeβ€”