CCDC62 (coiled-coil domain containing 62) is a nuclear receptor coactivator with dual roles in reproductive and neurological contexts. Functionally, CCDC62 preferentially enhances estrogen receptor beta (ERβ) transactivation through ligand-binding domain interactions 1, and also modulates progesterone, glucocorticoid, and androgen receptor activity at lower efficiency. The protein functions as a component of stage-specific Sertoli cell-germ cell communications during spermatogenesis, co-expressing with SOX9 in mature Sertoli cells 2. CCDC62 is required for normal spermiogenesis and likely plays a role in acrosome formation, as evidenced by downregulated CCDC62 expression in patients with acrosomal hypoplasia 3. Pathologically, CCDC62 variants associate with spermatogenic failure and represent a potential Parkinson's disease (PD) risk locus. The rs12817488 polymorphism shows gender-dependent PD association in Chinese populations, with the AA genotype correlating with increased CCDC62 protein expression in PD patients 4. However, this association demonstrates population-specific variations and remains inconsistent across ethnic groups 5. Mechanistically, psychotropic drugs including fluoxetine upregulate CCDC62 expression, potentially modulating PD risk through transcriptional pathways 6. These findings establish CCDC62 as a multifunctional protein linking reproductive function to complex neurological disease susceptibility.