Based on limited published evidence, CCDC159 functions during spermatid development, participating in centrosome reduction and formation of the sperm head-tail coupling apparatus (HTCA), ensuring proper flagellar attachment to the nuclear envelope. Beyond its established reproductive role, bioinformatics analyses have identified CCDC159 as a candidate gene associated with heart failure 1 and lung adenocarcinoma 2, though mechanistic relationships remain unclear and require further investigation.