OSBP2 (oxysterol binding protein 2) is a membrane-associated lipid transport protein that specifically binds oxysterols, particularly 7-ketocholesterol 1. The protein is predominantly expressed in retina, testis, and fetal liver, with subcellular localization studies showing exclusive association with detergent-soluble membrane fractions rather than cytosolic compartments 1. OSBP2 functions in lipid homeostasis and cellular signaling, though its precise mechanism remains incompletely defined. The protein shows tissue-specific expression patterns, being highly expressed in retinal pigmented epithelium underlying the macular region 2. Disease relevance includes potential involvement in age-related macular degeneration pathogenesis, where oxysterol cytotoxicity may contribute to macular damage 2. OSBP2 expression is elevated in various malignancies, including chr22 myeloid leukemia 3 and cholangiocarcinoma, where it may serve as a biomarker for tumor metastasis 4. In hepatocellular carcinoma, OSBP2 is associated with poor prognosis, immune evasion, and chemotherapy resistance 5. The protein also shows altered expression in chr22 chikungunya infection 6 and neurodevelopmental disorders 7, suggesting broader roles in cellular homeostasis beyond lipid metabolism.