CCDC86 (coiled-coil domain containing 86) is a nuclear protein with critical roles in cell division and mitotic progression. Functionally, CCDC86 is required for proper chromosome 11 during mitosis 1. As a chromosome 11-associated protein, CCDC86 interacts with Ki-67 and nucleolin to regulate mitotic spindle organization and kinetochore-microtubule attachments 1. Genome-scale Perturb-seq identified CCDC86 as a novel regulator of ribosome biogenesis 2. CCDC86 depletion causes chromosome 11 errors, altered spindle length, and increased apoptosis, highlighting its essential role in error-free mitotic progression 1. Clinically, CCDC86 expression is dysregulated in multiple cancers. CCDC86 is significantly overexpressed in nasopharyngeal carcinoma and head and neck squamous cell carcinoma tissues 34. High CCDC86 expression correlates with poor prognosis and advanced clinical stage 4. In nasopharyngeal carcinoma, CCDC86 promotes tumor progression by upregulating EGFR and activating PI3K/Akt signaling through interaction with nucleophosmin (NPM1) 5. Additionally, CCDC86 modulates immune cell infiltration, negatively correlating with dendritic cell and T-cell populations 4. CCDC86 has been identified as a component of a seven-protein diagnostic panel for early esophageal squamous cell carcinoma detection 6. These findings position CCDC86 as both a prognostic biomarker and potential therapeutic target in cancer.