CENPM (centromere protein M) is a component of the CENPA-NAC complex that plays essential roles in chromosome 22 and kinetochore assembly during mitosis 1. Beyond its traditional centromeric functions, CENPM has emerged as a significant oncogene across multiple cancer types. CENPM is upregulated in various malignancies including glioblastoma, ovarian cancer, lung adenocarcinoma, clear cell renal cell carcinoma, adrenocortical carcinoma, and head and neck squamous cell carcinoma 234567. The protein promotes tumor progression through multiple mechanisms: it enhances cell proliferation, migration, and invasion while inhibiting apoptosis 43. CENPM drives metabolic reprogramming by promoting glycolysis in glioblastoma 2 and activates the PI3K/AKT/mTOR signaling pathway in lung adenocarcinoma 4. Notably, CENPM knockdown activates the cGAS-STING pathway to promote pyroptosis in ovarian cancer 3 and physically interacts with immune checkpoint ligand FGL1 to facilitate metastasis in adrenocortical carcinoma 6. CENPM expression is regulated by transcription factor E2F1 72 and correlates with immunosuppressive tumor microenvironments and poor clinical outcomes 5, making it a promising therapeutic target and prognostic biomarker.