CCDC93 is a coiled-coil domain-containing protein that functions as a critical scaffolding subunit of the Commander complex, a 16-protein assembly essential for endosomal cargo recycling 1. CCDC93 works together with CCDC22 and COMMD proteins (COMMD1-10) to form the CCC complex, which couples with the Retriever subcomplex (VPS35L, VPS26C, VPS29) to coordinate SNX17-dependent recycling of over 120 cell surface proteins back from endosomes to the plasma membrane 2. This recycling machinery specifically recognizes transmembrane cargo containing ΦxNPxY/F motifs in their cytoplasmic domains 3. Clinically, CCDC93 mutations cause Ritscher-Schinzel syndrome (RSS), a congenital disorder characterized by cerebellar, cardiac, and craniofacial malformations, demonstrating that Commander complex dysfunction impairs tissue-specific surface protein presentation critical for development 3. Beyond RSS, Commander complex variants associate with Parkinson's disease risk through dysregulation of lysosomal homeostasis 4. Additionally, CCDC93 participates in LDL receptor trafficking and plasma lipid metabolism 5. The protein's evolutionary conservation extends to plants, where it regulates endosomal trafficking during root development 6.