CCP110 (centriolar coiled-coil protein 110) is a critical regulator of both centrosome duplication and ciliogenesis. The protein acts as a key negative regulator of ciliogenesis by capping the mother centriole and preventing cilia formation in collaboration with CEP97 1. At the molecular level, CCP110 autonomously binds microtubule plus ends, blocks their growth, and inhibits depolymerization, while directly interacting with CPAP to impose extremely slow processive microtubule growth essential for centriole elongation 2. During ciliogenesis, CCP110 must be removed from the mother centriole by EHD1 and MICAL-L1 to permit cilium formation 1. CCP110 also plays essential roles in spindle assembly, as it is a component of the human oocyte microtubule organizing center (huoMTOC) that regulates spindle formation during meiosis 3. Disease relevance includes potential associations with tuberculous meningitis susceptibility 4 and ciliopathies through its interactions with CEP76 5. CCP110 expression is also regulated by glucocorticoid signaling during renal development, with disrupted signaling causing ciliogenesis defects 6. These findings establish CCP110 as a fundamental component controlling centrosome-cilium biology and cellular organization.