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10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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CD101
CD101 molecule
Chromosome 1 · 1p13.1
NCBI Gene: 9398Ensembl: ENSG00000134256.14HGNC: HGNC:5949UniProt: Q93033
28PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
extracellular exosomemembranecell surface receptor signaling pathwayplasma membranediabetes mellitusdiabetic neuropathytype 2 diabetes mellitusTownes-Brocks syndrome
✦AI Summary

Unable to provide a gene function summary for CD101 based on the provided PubMed abstracts. The abstracts supplied focus exclusively on antifungal therapeutics (rezafungin, fosmanogepix, ibrexafungerp, olorofim), fungal infections (Candida, Aspergillus, Pneumocystis), and eosinophil biology—none of which contain information about CD101 molecule function. While one abstract 1 discusses CD101 as a surface marker distinguishing lung-resident eosinophil subsets (CD101lo versus CD101hi), this single reference provides insufficient data to establish CD101's primary function, mechanisms of T-cell inhibition, or clinical significance in disease contexts. To accurately summarize CD101's role as a T-cell proliferation inhibitor, its effects on IL-2 signaling, calcium mobilization, and potential involvement in leukemic disease markers, abstracts specifically investigating CD101 molecular mechanisms and disease associations would be required. The provided literature set does not support generating a comprehensive, evidence-based gene function summary.

Sources cited
1
CD101 identified as surface marker on eosinophils, with resident lung eosinophils being CD101lo and inflammatory eosinophils being CD101hi
PMID: 27548519
⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsⓘ20
diabetes mellitusOpen Targets
0.41Moderate
diabetic neuropathyOpen Targets
0.35Weak
type 2 diabetes mellitusOpen Targets
0.17Weak
Townes-Brocks syndromeOpen Targets
0.08Suggestive
type 1 diabetes mellitusOpen Targets
0.08Suggestive
gliomaOpen Targets
0.07Suggestive
colitisOpen Targets
0.07Suggestive
infectionOpen Targets
0.05Suggestive
X-linked severe congenital neutropeniaOpen Targets
0.05Suggestive
nonimmune chronic idiopathic neutropenia of adultsOpen Targets
0.05Suggestive
neutropenia, severe congenital, 2, autosomal dominantOpen Targets
0.05Suggestive
Blackfan-Diamond anemiaOpen Targets
0.05Suggestive
Neutropenia - monocytopenia - deafnessOpen Targets
0.04Suggestive
neutropenia-monocytopenia-deafness syndromeOpen Targets
0.04Suggestive
autosomal recessive severe congenital neutropenia due to CSF3R deficiencyOpen Targets
0.04Suggestive
inflammatory bowel diseaseOpen Targets
0.04Suggestive
HIV infectionOpen Targets
0.04Suggestive
X-linked sideroblastic anemia 1Open Targets
0.04Suggestive
neutropenia, severe congenital, 10, autosomal recessiveOpen Targets
0.04Suggestive
neutropenia, severe congenital, 1, autosomal dominantOpen Targets
0.04Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
MS4A18Shared pathway100%MS4A13Shared pathway100%ADGRD2Shared pathway100%MS4A10Shared pathway100%MS4A6EShared pathway100%MS4A15Shared pathway100%
Tissue Expression6 tissues
Bone Marrow
100%
Lung
30%
Liver
7%
Heart
6%
Ovary
6%
Brain
5%
Gene Interaction Network
Click a node to explore
CD101MS4A18MS4A13ADGRD2MS4A10MS4A6EMS4A15
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q93033
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.89LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.73 [0.61–0.89]
RankingsWhere CD101 stands among ~20K protein-coding genes
  • #12,325of 20,598
    Most Researched28
  • #7,965of 17,882
    Most Constrained (LOEUF)0.89
Genes detectedCD101
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin.
PMID: 34626339
Drugs · 2021
1.00
2
PMID: 38235979
Clin Microbiol Rev · 2024
0.90
3
Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial.
PMID: 36442484
Lancet · 2023
0.80
4
New treatment options for critically important WHO fungal priority pathogens.
PMID: 38461942
Clin Microbiol Infect · 2025
0.70
5
Rezafungin: A Review in Invasive Candidiasis.
PMID: 39913021
Drugs · 2025
0.60